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Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing

  • 작성자

    Jong-Soo Lee
  • 작성일자

    2021-12-30
  • 조회수

    362
Jong-Soo Lee( jongsool@cnu.ac.kr )
2010-present Assistant & Associate Professor, Professor, Veterinary Microbiology,
College of Veterinary Medicine, Chungnam National University
2008-2010 Research fellow, University of Southern California, USA
(Advisor: Dr. Jae U. Jung)
2006-2007 Research fellow, Harvard Medical School, USA (Advisor: Dr. Jae U. Jung)
2001-2006 Senior Research Scientist, Technical Research Center, BioLeaders Corporation, Daejeon, Korea
1996-2001 Master & PhD of Veterinary Medicine, College of Veterinary Medicine,
Chungnam National University, Daejeon, Korea
1992-1996 Bachelor of Veterinary Medicine (DVM), College of Veterinary Medicine,
Chungnam National University, Daejeon, Korea

Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing

A harmonized balance between positive and negative regulation of pattern recognition receptor (PRR)-initiated immune responses is required to achieve the most favorable outcome for the host. This balance is crucial because it must not only ensure activation of the first line of defense against viral infection but also prevent inappropriate immune activation, which results in autoimmune diseases. Recent studies have shown how signal transduction pathways initiated by PRRs are positively and negatively regulated by diverse modulators to maintain host immune homeostasis. However, viruses have developed strategies to subvert the host antiviral response and establish infection. Viruses have evolved numerous genes encoding immunomodulatory proteins that antagonize the host immune system. This review focuses on the current state of knowledge regarding key host factors that regulate innate immune signaling molecules upon viral infection and discusses evidence showing how specific viral proteins counteract antiviral responses via immunomodulatory strategies.

Exp Mol Med. 2021 Nov;53(11):1647-1668. doi: 10.1038/s12276-021-00691-y.
https://pubmed.ncbi.nlm.nih.gov/34782737/