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O-GlcNAcylation in health and neurodegenerative diseases

  • 작성자

    Jae-Ick Kim
  • 작성일자

    2021-12-30
  • 조회수

    371
Jae-Ick Kim( jikim220@unist.ac.kr )
2021-present Associate Professor, Department of Biological Sciences, Ulsan National Institute of Science and Technology
2017-2021 Assistant Professor, School of Life Sciences, Ulsan National Institute of Science and Technology
2013-2016 Postdoctoral Fellow, Department of Neurosurgery, Stanford University
2012-2013 Postdoctoral Fellow, Department of Biological Sciences, Seoul National University
2005-2012 PhD, Department of Biological Sciences, Seoul National University
1997-2005 BS, Department of Electrical Engineering, Seoul National University
BS, Department of Biological Sciences, Seoul National University

O-GlcNAcylation in health and neurodegenerative diseases

O-GlcNAcylation is a posttranslational modification that adds O-linked β-N-acetylglucosamine (O-GlcNAc) to serine or threonine residues of many proteins. This protein modification interacts with key cellular pathways involved in transcription, translation, and proteostasis. Although ubiquitous throughout the body, O-GlcNAc is particularly abundant in the brain, and various proteins commonly found at synapses are O-GlcNAcylated. Recent studies have demonstrated that the modulation of O-GlcNAc in the brain alters synaptic and neuronal functions. Furthermore, altered brain O-GlcNAcylation is associated with either the etiology or pathology of numerous neurodegenerative diseases, while the manipulation of O-GlcNAc exerts neuroprotective effects against these diseases. Although the detailed molecular mechanisms underlying the functional roles of O-GlcNAcylation in the brain remain unclear, O-GlcNAcylation is critical for regulating diverse neural functions, and its levels change during normal and pathological aging. In this review, we will highlight the functional importance of O-GlcNAcylation in the brain and neurodegenerative diseases.

Exp Mol Med. 2021 Nov 26. doi: 10.1038/s12276-021-00709-5.
https://pubmed.ncbi.nlm.nih.gov/34837015