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BmB Reports

Stromal cells and epigenetics: Emerging key players of chronic inflammatory skin diseases

  • 작성자

    Jihye Kim
  • 작성일자

    2024-03-22
  • 조회수

    1407
Name: Jihye Kim ( jihye.kim@hnu.kr )
2023-presentAssistant Professor, Department of Biopharmaceutical Engineering, Hannam University
2021-2023Postdoctoral research fellow, Swiss Federal Institute of Technology Zurich, Switzerland
2016-2021Ph.D., Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich, Switzerland
Name: Michael Detmar ( michael.detmar@pharma.ethz.ch )
2022-presentProfessor emeritus, ETH Zurich, Switzerland
2004-2022Professor, Institute of Pharmaceutical Sciences, ETH Zurich, Switzerland
1998-2006Associate Professor of Dermatology, Harvard Medical School, Boston, USA
1993-1997Visiting Assistant Professor of Pathology and Dermatology, Harvard Medical School, Boston, USA
1990-1993Assistant Professor of Dermatology, Free University of Berlin, Germany

Stromal cells and epigenetics: Emerging key players of chronic inflammatory skin diseases

Epigenetic alterations play a crucial role in developmental processes, tissue regeneration, and cellular differentiation. Epigenetic changes are dynamically reversible, and various drugs that target DNA methyltransferases or histone deacetylases have demonstrated the ability to restore normal epigenetic patterns in a number of diseases. While the involvement of epigenetic modifications has been identified in chronic inflammatory diseases, their specific impact on skin inflammation in stromal cells remains unclear. This mini review explores the role of stromal cells in chronic inflammatory skin diseases, focusing on the epigenetic modifications of stromal cells such as fibroblasts, blood and lymphatic endothelial cells in both healthy and diseased skin. We also provide an overview of recent findings that highlight the contribution of stromal cells, including fibroblasts, to inflammatory and remodeling processes through epigenetic changes in the context of chronic inflammatory conditions. Investigating the epigenetic reprogramming of stromal cells could offer a novel approach for the treatment of chronic inflammatory skin diseases.