생화학분자생물학회

	Name: Jihye Kim ( jihye.kim@hnu.kr )
	2023-present	Assistant Professor, Department of Biopharmaceutical Engineering, Hannam University
	2021-2023	Postdoctoral research fellow, Swiss Federal Institute of Technology Zurich, Switzerland
	2016-2021	Ph.D., Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich, Switzerland

	Name: Michael Detmar ( michael.detmar@pharma.ethz.ch )
	2022-present	Professor emeritus, ETH Zurich, Switzerland
	2004-2022	Professor, Institute of Pharmaceutical Sciences, ETH Zurich, Switzerland
	1998-2006	Associate Professor of Dermatology, Harvard Medical School, Boston, USA
	1993-1997	Visiting Assistant Professor of Pathology and Dermatology, Harvard Medical School, Boston, USA
	1990-1993	Assistant Professor of Dermatology, Free University of Berlin, Germany

Stromal cells and epigenetics: Emerging key players of chronic inflammatory skin diseases

Epigenetic alterations play a crucial role in developmental processes, tissue regeneration, and cellular differentiation. Epigenetic changes are dynamically reversible, and various drugs that target DNA methyltransferases or histone deacetylases have demonstrated the ability to restore normal epigenetic patterns in a number of diseases. While the involvement of epigenetic modifications has been identified in chronic inflammatory diseases, their specific impact on skin inflammation in stromal cells remains unclear. This mini review explores the role of stromal cells in chronic inflammatory skin diseases, focusing on the epigenetic modifications of stromal cells such as fibroblasts, blood and lymphatic endothelial cells in both healthy and diseased skin. We also provide an overview of recent findings that highlight the contribution of stromal cells, including fibroblasts, to inflammatory and remodeling processes through epigenetic changes in the context of chronic inflammatory conditions. Investigating the epigenetic reprogramming of stromal cells could offer a novel approach for the treatment of chronic inflammatory skin diseases.