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Sirtuins are Crucial Regulators of T Cell Metabolism and Functions

  • 작성자

    Sungjune Kim
  • 작성일자

    2022-07-20
  • 조회수

    262
Sungjune Kim, MD, PhD( Sungjune.kim@moffitt.org )
Year 2022Affiliation & Position: Director, Radiation Oncology Translational Research, Associate Member, Department of Radiation Oncology and Immunology, H. Lee. Moffitt Cancer Center & Research Institute, Associate Professor, University of South Florida

Sirtuins are Crucial Regulators of T Cell Metabolism and Functions

It is well known that metabolism underlies T cell differentiation and functions. The pathways regulating T cell metabolism and function are interconnected, and changes in T cell metabolic activity directly impact the effector functions and fate of T cells. Thus, understanding how metabolic pathways influence immune responses and ultimately affect disease progression is paramount. Epigenetic and posttranslational modification mechanisms have been found to control immune responses and metabolic reprogramming. Sirtuins are NAD+-dependent histone deacetylases that play key roles during cellular responses to a variety of stresses and have recently been reported to have potential roles in immune responses. Therefore, sirtuins are of significant interest as therapeutic targets to treat immune-related diseases and enhance antitumor immunity. This review aims to illustrate the potential roles of sirtuins in different subtypes of T cells during the adaptive immune response.

Exp. Mol. Med. 2022 Mar;54(3):207-215. doi: 10.1038/s12276-022-00739-7. Epub 2022 Mar 16