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BMB Reports

Role of post-translational modifications in the alpha-synuclein aggregation-related pathogenesis of Parkinson’s disease

  • 작성자

    Yohan Oh
  • 작성일자

    2022-07-19
  • 조회수

    301
Name: Yohan Oh ( yoh@hanyang.ac.kr )
2021-present Associate Professor, Department of Biomedical Science, Graduate School of Biomedical Science & Engineering, Hanyang University; Department of Biochemistry and Molecular Biology, College of Medicine, Hanyang University, Seoul, Korea
2018-2021 Assistant Professor, Department of Biochemistry and Molecular Biology, College of Medicine, Hanyang University; Department of Biomedical Science, Graduate School of Biomedical Science & Engineering, Hanyang University, Seoul, Korea
2013-2018 Post-Doctoral Fellow, Institute for Cell Engineering / Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
2012-2013 Post-Doctoral Fellow, BK21 Yonsei Biomolecule Research Initiative, Yonsei University, Seoul, Korea
2005-2012 Ph.D., Department of Systems Biology, College of Live Science and Biotechnology, Yonsei University, Seoul, Korea
1998-2005 B.S., Division of Natural Sciences, College of Science, Yonsei University, Seoul, Korea

Role of post-translational modifications in the alpha-synuclein aggregation-related pathogenesis of Parkinson’s disease

Together with neuronal loss, the existence of insoluble inclusions of alpha-synuclein (α-syn) in the brain is widely accepted as a hallmark of synucleinopathies including Parkinson’s disease (PD) and multiple system atrophy. As the α-syn aggregates are deeply involved in the progression of the pathology, there have been many attempts to demonstrate the mechanism of the aggregation and its causative factors including post-translational modifications (PTMs). Although all the details are not yet completely discovered, it is obvious that modifications such as phosphorylation and ubiquitination can alter the characteristics of α-syn to have certain effects on the aggregation process in PD, either facilitating or inhibiting the fibrillization. In the present work, we reviewed the research showing the significant impacts of PTMs in α-syn on its aggregation. Furthermore, the PTMs modulating α-syn aggregation-induced cell death have been discussed.


BMB Rep. 2022 Jun 23;5630. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35733294/