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Liver progenitor cell-driven liver regeneration

  • 작성자

    관리자
  • 작성일자

    2020-11-23
  • 조회수

    276
Donghun Shin (donghuns@pitt.edu)
2016-present Associate Professor, University of Pittsburgh School of Medicine, USA
2010-2016 Assistant Professor, University of Pittsburgh School of Medicine, USA
2005-2010 Postdoctoral Associate, University of California, San Francisco, USA
1998-2005 Ph.D. Student, California Institute of Technology, Pasadena, USA
1995-1997 M.S. Student, Department of Molecular Biology, Seoul National University, South Korea
1989-1995 Undergraduate Student, Department of Molecular Biology, Seoul National University, South Korea

Liver progenitor cell-driven liver regeneration

The liver is a highly regenerative organ, but its regenerative capacity is compromised in severe liver diseases. Hepatocyte-driven liver regeneration that involves the proliferation of preexisting hepatocytes is a primary regeneration mode. On the other hand, liver progenitor cell (LPC)-driven liver regeneration that involves dedifferentiation of biliary epithelial cells or hepatocytes into LPCs, LPC proliferation, and subsequent differentiation of LPCs into hepatocytes is a secondary mode. This secondary mode plays a significant role in liver regeneration when the primary mode does not effectively work, as observed in severe liver injury settings. Thus, promoting LPC-driven liver regeneration may be clinically beneficial to patients with severe liver diseases. In this review, we describe the current understanding of LPC-driven liver regeneration by exploring current knowledge on the activation, origin, and roles of LPCs during regeneration. We also describe animal models used to study LPC-driven liver regeneration, given their potential to further deepen our understanding of the regeneration process. This understanding will eventually contribute to developing strategies to promote LPC-driven liver regeneration in patients with severe liver diseases.

Exp Mol Med. 2020 Aug;52(8):1230-1238. doi: 10.1038/s12276-020-0483-0.
https://pubmed.ncbi.nlm.nih.gov/32796957/