간행물

생화학분자생물학회입니다.


EMM

Heterochromatin: an epigenetic point of view in aging

  • 작성자

    관리자
  • 작성일자

    2020-11-23
  • 조회수

    181
Jong-Hyuk Lee (Jong-Hyuk.lee@nih.gov)
2016-present Postdoctoral Research Scientist, National Institute on Aging,National institute of Health, USA
2009-2015 Ph.D., Biomedical Science, Department of Biomedical Science, Seoul National University, South Korea
2006-2009 M.S., Genetic engineering, Department of Natural Sciences, Seoul National University, South Korea

Heterochromatin: an epigenetic point of view in aging

Aging is an inevitable process of life. Defined by progressive physiological and functional loss of tissues and organs, aging increases the risk of mortality for the organism. The aging process is affected by various factors, including genetic and epigenetic ones. Here, we review the chromatin-specific epigenetic changes that occur during normal (chronological) aging and in premature aging diseases. Taking advantage of the reversible nature of epigenetic modifications, we will also discuss possible lifespan expansion strategies through epigenetic modulation, which was considered irreversible until recently.

Exp Mol Med. 2020 Sep 4. doi: 10.1038/s12276-020-00497-4. Online ahead of print.
https://www.ncbi.nlm.nih.gov/pubmed/32887933