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BMB Reports

Epitranscriptomic regulation of transcriptome plasticity in development and diseases of the brain

  • 작성자

    관리자
  • 작성일자

    2020-11-23
  • 조회수

    230
Name: Ki-Jun Yoon Email: kijunyoon@kaist.ac.kr
2018-present Assistant professor, Department of Biological Sciences, KAIST, Korea
2010-2018 Postdoctoral research fellow, Johns Hopkins University, USA
2008-2009 Postdoctoral research fellow, Seoul National University, Korea
2003-2008 Ph.D., Department of Life Science, POSTECH, Korea

Epitranscriptomic regulation of transcriptome plasticity in development and diseases of the brain

Proper development of the nervous system is critical for its function, and deficits in neural development have been implicated in many brain disorders. A precise and predictable developmental schedule requires highly coordinated gene expression programs that orchestrate the dynamics of the developing brain. Especially, recent discoveries showing that various mRNA chemical modifications can affect RNA metabolism including decay, transport, splicing, and translation in cell type- and tissue-specific manner, leading to the emergence of the field of epitranscriptomics. Moreover, accumulating evidences showed that certain types of RNA modifications are predominantly found in the developing brain and their dysregulation disrupts not only the developmental processes, but also neuronal activities, suggesting that epitranscriptomic mechanisms play critical post-transcriptional regulatory roles in development of the brain and etiology of brain disorders. Here, we review recent advances in our understanding of molecular regulation of transcriptome plasticity by RNA modifications, and how the many regulatory systems work in harmony to coordinate the precise developmental program.

https://pubmed.ncbi.nlm.nih.gov/33148378/
BMB Rep 2020 Nov 4;5176. Online ahead of print