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Chromatin and noncoding RNA-mediated mechanisms of gastric tumorigenesis

  • 작성자

    Tae-Hee Kim
  • 작성일자

    2023-03-28
  • 조회수

    677
Tae-Hee Kim( tae-hee.kim@sickkids.ca )
2022 – presentAssociate Professor, Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
2021 – presentSenior Scientist, Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
2014 – 2022Assistant Professor, Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
2014 – 2021Scientist, Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
2011 – 2014Instructor, Gut stem cells and disease, Medicine, Harvard Medical School, Boston, Massachusetts, USA.
2007 – 2011Post doctoral fellow, Gut stem cells and disease, Medical Oncology, Harvard University and Dana-Farber Cancer Institute, Boston, Massachusetts, USA. Supervisor(s): Dr. Ramesh Shivdasani
1999 – 2006Ph.D., Cell Biology and Genetics, Cornell University and Sloan-Kettering Institute, New York, New York, USA. Supervisor(s): Dr. Lee Niswander
1997 – 1999M.Sc., Biology, University of Illinois at Urbana Champaign, Urbana Champaign, Illinois, USA. Supervisor(s): Dr. Bettina Francis and Michael Plewa
1991 – 1996B.Sc., Biology, Sungkyunkwan University, Suwon, Gyonggi-do, South Korea.

Chromatin and noncoding RNA-mediated mechanisms of gastric tumorigenesis

Gastric cancer (GC) is one of the most common and deadly cancers in the world. It is a multifactorial disease highly influenced by environmental factors, which include radiation, smoking, diet, and infectious pathogens. Accumulating evidence suggests that epigenetic regulators are frequently altered in GC, playing critical roles in gastric tumorigenesis. Epigenetic regulation involves DNA methylation, histone modification, and noncoding RNAs. While it is known that environmental factors cause widespread alterations in DNA methylation, promoting carcinogenesis, the chromatin- and noncoding RNA-mediated mechanisms of gastric tumorigenesis are still poorly understood. In this review, we focus on discussing recent discoveries addressing the roles of histone modifiers and noncoding RNAs and the mechanisms of their interactions in gastric tumorigenesis. A better understanding of epigenetic regulation would likely facilitate the development of novel therapeutic approaches targeting specific epigenetic regulators in GC.

Exp Mol Med 2023 Jan;55(1):22-31. doi: 10.1038/s12276-023-00926-0.
https://pubmed.ncbi.nlm.nih.gov/36653445/