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Endothelial senescence in vascular diseases: current understanding and future opportunities in senotherapeutics

  • 작성자

    Sung Young Kim
  • 작성일자

    2023-03-28
  • 조회수

    693
Sung Young Kim( palelamp@kku..ac.kr )
2023-presentProfessor, Department of Biochemistry, Konkuk University School of Medicine
2021-2022Visiting scholar, Department of Genetics, University of Cambridge
2017-2022Associate Professor, Department of Biochemistry, Konkuk University School of Medicine
2013-2016Assistant Professor, Department of Biochemistry, Konkuk University School of Medicine
2011-2012Assistant Professor, Department of Biochemistry, Gachon University School of Medicine
2011PhD, Department of Biochemistry, Seoul National University College of Medicine (M.Sc/Ph.D combined program)
2008MD, Konkuk University College of Medicine

Endothelial senescence in vascular diseases: current understanding and future opportunities in senotherapeutics

Senescence compromises the essential role that the endothelium plays in maintaining vascular homeostasis, so promoting endothelial dysfunction and the development of age-related vascular diseases. Their biological and clinical significance calls for strategies for identifying and therapeutically targeting senescent endothelial cells. While senescence and endothelial dysfunction have been studied extensively, distinguishing what is distinctly endothelial senescence remains a barrier to overcome for an effective approach to addressing it. Here, we review the mechanisms underlying endothelial senescence and the evidence for its clinical importance. Furthermore, we discuss the current state and the limitations in the approaches for the detection and therapeutic intervention of target cells, suggesting potential directions for future research

Exp Mol Med. 2023 Jan;55(1):1-12. doi: 10.1038/s12276-022-00906-w.
https://pubmed.ncbi.nlm.nih.gov/36599934/