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BMB Reports

Mechanosensitive ion channels in apoptosis and ferroptosis: focusing on the role of Piezo1

  • 작성자

    Jeongeun Hyun
  • 작성일자

    2023-03-28
  • 조회수

    1649
Name: Jeongeun Hyun ( j.hyun@dankook.ac.kr )
2020-presentAssistant Professor, Institute of Tissue Regeneration Engineering (ITREN), Department of Nanobiomedical Science, Mechanobiology Dental Medicine Research Center, Dankook University
2017-2020Postdoctoral Associate, Duke University Medical Center and Health System, Duke University, USA
2016-2017Postdoctoral Researcher, BK21 Plus Research Group Longevity and Marine Biotechnology, Pusan National University
2013-2016Ph.D., Department of Integrated Biological Science, Pusan National University
2011-2013M.S., Department of Biological Sciences, Pusan National University

Mechanosensitive ion channels in apoptosis and ferroptosis: focusing on the role of Piezo1

Mechanosensitive ion channels sense mechanical stimuli applied directly to the cellular membranes or indirectly through their tethered components, provoking cellular mechanoresponses. Among others, Piezo1 mechanosensitive ion channel is a relatively novel Ca2+-permeable channel that is primarily present in non-sensory tissues. Recent studies have demonstrated that Piezo1 plays an important role in Ca2+-dependent cell death, including apoptosis and ferroptosis, in the presence of mechanical stimuli. It has also been proven that cancer cells are sensitive to mechanical stresses due to higher expression levels of Piezo1 compared to normal cells. In this review, we discuss Piezo1-mediated cell death mechanisms and therapeutic strategies to inhibit or induce cell death by modulating the activity of Piezo1 with pharmacological drugs or mechanical perturbations induced by stretch and ultrasound.


BMB Rep. 2023 Mar;56(3);145-152. doi: 10.5483/BMBRep.2023-0002.
https://pubmed.ncbi.nlm.nih.gov/36724905/