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New insights into the epitranscriptomic control of pluripotent stem cell fate

  • 작성자

    Yong Jun Kim
  • 작성일자

    2022-11-15
  • 조회수

    395
Yong Jun Kim( yjkim1@khu.ac.kr )
2020-present Associate professor, Department of Pathology, College of Medicine, Kyung Hee University, Republic of Korea
2016-2020 Assistant professor, Department of Pathology, College of Medicine, Kyung Hee University, Republic of Korea
2011-2016 Postdoctoral fellow, Department of Neurology, Johns Hopkins University School of Medicine, USA
2008-2011 PhD in Biomedical Science, Kyung Hee University

New insights into the epitranscriptomic control of pluripotent stem cell fate

Each cell in the human body has a distinguishable fate. Pluripotent stem cells are challenged with a myriad of lineage differentiation options. Defects are more likely to be fatal to stem cells than to somatic cells due to the broad impact of the former on early development. Hence, a detailed understanding of the mechanisms that determine the fate of stem cells is needed. The mechanisms by which human pluripotent stem cells, although not fully equipped with complex chromatin structures or epigenetic regulatory mechanisms, accurately control gene expression and are important to the stem cell field. In this review, we examine the events driving pluripotent stem cell fate and the underlying changes in gene expression during early development. In addition, we highlight the role played by the epitranscriptome in the regulation of gene expression that is necessary for each fate-related event.

Exp Mol Med. 2022 Oct 21;54(10). doi: 10.1038/s12276-022-00824-x.
https://pubmed.ncbi.nlm.nih.gov/36266446/