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BMB Reports

Function of gaseous hydrogen sulfide in liver disease

  • 작성자

    Seung-Soon Im
  • 작성일자

    2022-11-15
  • 조회수

    177
Name: Seung-Soon Im ( ssim73@kmu.ac.kr )
2012-present Professor, Department of Physiology, Keimyung University School of Medicine
2009-2012 Staff Scientist, Sanford Burnham Presby Medical Research Institute, USA
2007-2009 Postdoctoral research fellow, University of California, Irvine, USA
2006-2007 Research Instructor, Yonsei University School of Medicine, Korea
2002-2006 Ph.D., Yonsei University, Korea
Name: Jae-Ho Lee ( hoyaya86@naver.com )
2020-present Postdoctoral Fellow, Department of Physiology, Keimyung University School of Medicine
2016-2020 Ph.D., Department of Physiology, Keimyung University School of Medicine
2013-2015 M.S., Department of Physiology, Keimyung University School of Medicine
2005-2012 B.S., Department of Biotechnology, Konkuk University

Function of gaseous hydrogen sulfide in liver disease

Over the past few years, hydrogen sulfide (H2S) has been shown to exert several biological functions in mammalian. The endogenous production of H2S is mainly mediated by cystathione β-synthase (CBS), cystathione γ-lyase (CSE) and 3-mercaptopyruvate sulfur transferase (MPST). These enzymes are broadly expressed in liver tissue and regulates liver function by working on a variety of molecular targets. As an important regulator of liver function, H2S is critically involved in the pathogenesis of various liver diseases, such as non-alcoholic steatohepatitis (NASH), liver fibrosis and liver cancer. Targeting H2S-generating enzymes may be a therapeutic strategy for controlling liver diseases. This review described the function of H2S in liver disease and summarized recent characterized role of H2S in several cellular process of the liver.


BMB Rep. 2022 Oct;55(10):481-487. DOI: 10.5483/BMBRep.2022.55.10.124.

https://pubmed.ncbi.nlm.nih.gov/36195563/