생화학분자생물학회입니다.
Function of gaseous hydrogen sulfide in liver disease
작성자
Seung-Soon Im작성일자
2022-11-15조회수
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Name: Seung-Soon Im ( ssim73@kmu.ac.kr ) | |
2012-present | Professor, Department of Physiology, Keimyung University School of Medicine | |
2009-2012 | Staff Scientist, Sanford Burnham Presby Medical Research Institute, USA | |
2007-2009 | Postdoctoral research fellow, University of California, Irvine, USA | |
2006-2007 | Research Instructor, Yonsei University School of Medicine, Korea | |
2002-2006 | Ph.D., Yonsei University, Korea | |
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Name: Jae-Ho Lee ( hoyaya86@naver.com ) | |
2020-present | Postdoctoral Fellow, Department of Physiology, Keimyung University School of Medicine | |
2016-2020 | Ph.D., Department of Physiology, Keimyung University School of Medicine | |
2013-2015 | M.S., Department of Physiology, Keimyung University School of Medicine | |
2005-2012 | B.S., Department of Biotechnology, Konkuk University |
Function of gaseous hydrogen sulfide in liver disease
Over the past few years, hydrogen sulfide (H2S) has been shown to exert several biological functions in mammalian. The endogenous production of H2S is mainly mediated by cystathione β-synthase (CBS), cystathione γ-lyase (CSE) and 3-mercaptopyruvate sulfur transferase (MPST). These enzymes are broadly expressed in liver tissue and regulates liver function by working on a variety of molecular targets. As an important regulator of liver function, H2S is critically involved in the pathogenesis of various liver diseases, such as non-alcoholic steatohepatitis (NASH), liver fibrosis and liver cancer. Targeting H2S-generating enzymes may be a therapeutic strategy for controlling liver diseases. This review described the function of H2S in liver disease and summarized recent characterized role of H2S in several cellular process of the liver.
BMB Rep. 2022 Oct;55(10):481-487. DOI:
10.5483/BMBRep.2022.55.10.124.