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BMB Reports

The translational landscape as regulated by the RNA helicase DDX3

  • 작성자

    Sekyung Oh
  • 작성일자

    2022-03-24
  • 조회수

    359
Name: Sekyung Oh ( ohskjhmi@cku.ac.kr )
2018-present Associate Professor, Department of Medical Science, Catholic Kwandong University College of Medicine, South Korea
2012-2018 Research Scientist, Stanford University School of Medicine, USA
2008-2012 Postdoctoral Associate, Yale University School of Medicine, USA
2000-2008 Ph.D., Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, USA
1997-1999 M.Ed., Department of Biology Education, Seoul National University, South Korea
1991-1996 B.S., Department of Biology Education, Seoul National University, South Korea

The translational landscape as regulated by the RNA helicase DDX3

Continuously renewing the proteome, translation is exquisitely controlled by a number of dedicated factors that interact with the ribosome. The RNA helicase DDX3 belonging to the DEAD box family has emerged as one of the critical regulators of translation, the failure of which is frequently observed in a wide range of proliferative, degenerative, and infectious diseases in humans. DDX3 unwinds double-stranded RNA molecules with coupled ATP hydrolysis and thereby remodels complex RNA structures present in various protein-coding and noncoding RNAs. By interacting with specific features on messenger RNAs (mRNAs) and 18S ribosomal RNA (rRNA), DDX3 facilitates translation, while repressing it under certain conditions. We review recent findings underlying these properties of DDX3 in diverse modes of translation, such as cap-dependent and cap-independent translation initiation, usage of upstream open reading frames, and stress-induced ribonucleoprotein granule formation. We further discuss how disease-associated DDX3 variants alter the translation landscape in the cell.


BMB Rep. 2022 Mar 3;5535. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35236544/