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BMB Reports

Odorant receptors in cancer

  • 작성자

    Chan Chung
  • 작성일자

    2022-03-24
  • 조회수

    356
Name: Chan Chung ( chungc@dgist.ac.kr )
2021-present Assistant Professor, Department of New Biology, DGIST
2020-2021 Research Investigator, University of Michigan, Medical School, USA
2015-2020 Postdoctoral research fellow, University of Michigan, Medical School, USA
2010-2015 Ph.D., Department of Molecular and Cellular Pathology, University of Michigan, Medical School, USA
Name: JaeHyung Koo ( jkoo001@dgist.ac.kr )
2017-present Professor, Dept. of New Biology, DGIST
2017-2018 Associated Vice-President for Research Affairs, DGIST
2011-2016 Visiting Professor, Johns Hopkins University Sch. of Medicine, Baltimore
2010-2017 Associate Professor, Dept. of Brain & Cognitive Sciences, DGIST
2003-2008 Assistant Professor, Dept. of Anatomy and Neurobiology Univ. of Maryland Sch. of Medicine, Baltimore, MD, USA
2000-2003 Postdoc. Fellow, Univ. of Maryland Sch. of Medicine, Baltimore
1997-2000 Ph.D., Department of Biochemistry, Yonsei University

Odorant receptors in cancer

Odorant receptors (ORs), the largest subfamily of G proteincoupled receptors, detect odorants in the nose. In addition, ORs were recently shown to be expressed in many nonolfactory tissues and cells, indicating that these receptors have physiological and pathophysiological roles beyond olfaction. Many ORs are expressed by tumor cells and tissues, suggesting that they may be associated with cancer progression or may be cancer biomarkers. This review describes OR expression in various types of cancer and the association of these receptors with various types of signaling mechanisms. In addition, the clinical relevance and significance of the levels of OR expression were evaluated. Namely, levels of OR expression in cancer were analyzed based on RNA-sequencing data reported in the Cancer Genome Atlas; OR expression patterns were visualized using t-distributed stochastic neighbor embedding (t-SNE); and the associations between patient survival and levels of OR expression were analyzed. These analyses of the relationships between patient survival and expression patterns obtained from an open mRNA database in cancer patients indicate that ORs may be cancer biomarkers and therapeutic targets.


BMB Reports 2022; 55(2): 72-80
https://pubmed.ncbi.nlm.nih.gov/35168702/