생화학분자생물학회입니다.
Stromal cells and epigenetics: Emerging key players of chronic inflammatory skin diseases
작성자
Jihye Kim작성일자
2024-03-22조회수
2115Name: Jihye Kim ( jihye.kim@hnu.kr ) | ||
2023-present | Assistant Professor, Department of Biopharmaceutical Engineering, Hannam University | |
2021-2023 | Postdoctoral research fellow, Swiss Federal Institute of Technology Zurich, Switzerland | |
2016-2021 | Ph.D., Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich, Switzerland |
Name: Michael Detmar ( michael.detmar@pharma.ethz.ch ) | ||
2022-present | Professor emeritus, ETH Zurich, Switzerland | |
2004-2022 | Professor, Institute of Pharmaceutical Sciences, ETH Zurich, Switzerland | |
1998-2006 | Associate Professor of Dermatology, Harvard Medical School, Boston, USA | |
1993-1997 | Visiting Assistant Professor of Pathology and Dermatology, Harvard Medical School, Boston, USA | |
1990-1993 | Assistant Professor of Dermatology, Free University of Berlin, Germany |
Stromal cells and epigenetics: Emerging key players of chronic inflammatory skin diseases
Epigenetic alterations play a crucial role in developmental processes, tissue regeneration, and cellular differentiation. Epigenetic changes are dynamically reversible, and various drugs that target DNA methyltransferases or histone deacetylases have demonstrated the ability to restore normal epigenetic patterns in a number of diseases. While the involvement of epigenetic modifications has been identified in chronic inflammatory diseases, their specific impact on skin inflammation in stromal cells remains unclear. This mini review explores the role of stromal cells in chronic inflammatory skin diseases, focusing on the epigenetic modifications of stromal cells such as fibroblasts, blood and lymphatic endothelial cells in both healthy and diseased skin. We also provide an overview of recent findings that highlight the contribution of stromal cells, including fibroblasts, to inflammatory and remodeling processes through epigenetic changes in the context of chronic inflammatory conditions. Investigating the epigenetic reprogramming of stromal cells could offer a novel approach for the treatment of chronic inflammatory skin diseases.