생화학분자생물학회

	Jong-Seok Moon( jongseok81@sch.ac.kr )
	2024-present	Associate Professor, Department of Pathology, College of Medicine Soonchunhyang University, South Korea
	2021-present	Associate Professor, Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, South Korea
	2017-2020	Assistant professor, Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, South Korea
	2015-2016	Instructor, Department of Medicine, Weill Cornell Medical College, U.S.A
	2013-2015	Postdoctoral Fellow, Department of Medicine, Weill Cornell Medical College, U.S.A
	2011-2013	Postdoctoral Fellow, Department of Medicine, Harvard Medical School, U.S.A
	2008-2011	PhD, Department of Medical Science, Yonsei University, South Korea
	2006-2008	MS, Department of Medical Science, Yonsei University, South Korea
	1999-2006	BS, Life Science, Hanyang University, South Korea

Pathological phenotypes of astrocytes in Alzheimer’s disease

Astrocytes are involved in various processes in the central nervous system (CNS). As the most abundant cell type in the CNS, astrocytes play an essential role in neuronal maintenance and support, synaptic activity, neuronal metabolism, and amyloid-beta (Aβ) clearance. Alzheimer’s disease (AD) is a neurodegenerative disorder associated with cognitive and behavioral impairment. The transformation of astrocytes is involved in various neurodegenerative diseases, such as AD. Since astrocytes have functional diversity and morphological and physiological heterogeneity in the CNS, AD-related astrocytes might show various pathological phenotypes during AD. Astrocytes developing pathological phenotypes could contribute to AD progression. In this review, we provide an overview of the pathological phenotypes of astrocytes in the context of AD, highlighting recent findings in human and mouse AD.

Exp Mol Med. 2024 Feb;56(1):95-99. doi: 10.1038/s12276-023-01148-0. Epub 2024 Jan 4.
https://pubmed.ncbi.nlm.nih.gov/38172603/