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HIRA vs. DAXX: the two axes shaping the histone H3.3 landscape

  • 작성자

    Jinmi Choi
  • 작성일자

    2024-03-22
  • 조회수

    1140
Jinmi Choi( jcws0517@skku.edu )
2020-presentResearch Professor, Department of Pharmacology, Sungkyunkwan University, South Korea
2014-2019Postdoctoral Researcher, Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Germany
2010-2014PhD, Biomedical Sciences, Seoul National University, South Korea
2008-2010MS, Biomedical Sciences, Seoul National University, South Korea
2002-2007BS, Biochemistry, Queen’s University, Canada

HIRA vs. DAXX: the two axes shaping the histone H3.3 landscape

H3.3, the most common replacement variant for histone H3, has emerged as an important player in chromatin dynamics for controlling gene expression and genome integrity. While replicative variants H3.1 and H3.2 are primarily incorporated into nucleosomes during DNA synthesis, H3.3 is under the control of H3.3-specific histone chaperones for spatiotemporal incorporation throughout the cell cycle. Over the years, there has been progress in understanding the mechanisms by which H3.3 affects domain structure and function. Furthermore, H3.3 distribution and relative abundance profoundly impact cellular identity and plasticity during normal development and pathogenesis. Recurrent mutations in H3.3 and its chaperones have been identified in neoplastic transformation and developmental disorders, providing new insights into chromatin biology and disease. Here, we review recent findings emphasizing how two distinct histone chaperones, HIRA and DAXX, take part in the spatial and temporal distribution of H3.3 in different chromatin domains and ultimately achieve dynamic control of chromatin organization and function. Elucidating the H3.3 deposition pathways from the available histone pool will open new avenues for understanding the mechanisms by which H3.3 epigenetically regulates gene expression and its impact on cellular integrity and pathogenesis.

Exp Mol Med. 2024 Feb 01; 56, pages251–263. doi: 10.1038/s12276-023-01145-3
https://pubmed.ncbi.nlm.nih.gov/38297159/