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Distinct characteristics of the DNA damage response in mammalian oocytes

  • 작성자

    Jeong Su Oh
  • 작성일자

    2024-03-22
  • 조회수

    1088
Jeong Su Oh( ohjs@skku.edu )
2016-presentProfessor, Department of Integrative Biotechnology, Sungkyunkwan University, Korea
2012-2016Assistant Professor, Department of Genetic Engineering, Sungkyunkwan University, Korea
2007-2012Post-doc, Center for Reproductive Science, University of California San Francisco (UCSF), USA
2004-2007Ph.D. Department of Life Science, Gwangju Institute of Science and Technology (GIST), Korea
2002-2004M.S. Department of Life Science, Gwangju Institute of Science and Technology (GIST), Korea
1994-2002B.S. Department of Genetic Engineering, Kyungpook National University, Korea

Distinct characteristics of the DNA damage response in mammalian oocytes

DNA damage is a critical threat that poses significant challenges to all cells. To address this issue, cells have evolved a sophisticated molecular and cellular process known as the DNA damage response (DDR). Among the various cell types, mammalian oocytes, which remain dormant in the ovary for extended periods, are particularly susceptible to DNA damage. The occurrence of DNA damage in oocytes can result in genetic abnormalities, potentially leading to infertility, birth defects, and even abortion. Therefore, understanding how oocytes detect and repair DNA damage is of paramount importance in maintaining oocyte quality and preserving fertility. Although the fundamental concept of the DDR is conserved across various cell types, an emerging body of evidence reveals striking distinctions in the DDR between mammalian oocytes and somatic cells. In this review, we highlight the distinctive characteristics of the DDR in oocytes and discuss the clinical implications of DNA damage in oocytes.

Exp Mol Med. 2024 Feb;56(2):319-328. doi: 10.1038/s12276-024-01178-2.
https://pubmed.ncbi.nlm.nih.gov/38355825/