간행물

생화학분자생물학회입니다.


EMM

Effects of fine particulate matter on bone marrow-conserved hematopoietic and mesenchymal stem cells: a systematic review

  • 작성자

    Sung-Ho Kook
  • 작성일자

    2024-03-22
  • 조회수

    1080
Sung-Ho Kook( kooksh@jbnu.ac.kr )
2019-presentAssociate Professor, Department of Bioactive Material Sciences,
Jeonbuk National University, South Korea
2015-2019Assistant Professor, Department of Bioactive Material Sciences, Jeonbuk National University, South Korea
2013-2015Research Professor, Institute for Molecular Biology and Genetics, Jeonbuk National University, South Korea
2009-2013Postdoctoral Associate, Department of Medicine,
University of Pittsburgh, Pennsylvania, USA
2005-2009Ph.D. in Cell Biology, Jeonbuk National University, South Korea
2002-2004M.S. in Meat Science, Chonnam National University, South Korea

Effects of fine particulate matter on bone marrow-conserved hematopoietic and mesenchymal stem cells: a systematic review

The harmful effects of fine particulate matter ≤2.5 µm in size (PM2.5) on human health have received considerable attention. However, while the impact of PM2.5 on the respiratory and cardiovascular systems has been well studied, less is known about the effects on stem cells in the bone marrow (BM). With an emphasis on the invasive characteristics of PM2.5, this review examines the current knowledge of the health effects of PM2.5 exposure on BM-residing stem cells. Recent studies have shown that PM2.5 enters the circulation and then travels to distant organs, including the BM, to induce oxidative stress, systemic inflammation and epigenetic changes, resulting in the reduction of BM-residing stem cell survival and function. Understanding the broader health effects of air pollution thus requires an understanding of the invasive characteristics of PM2.5 and its direct influence on stem cells in the BM. As noted in this review, further studies are needed to elucidate the underlying processes by which PM2.5 disturbs the BM microenvironment and inhibits stem cell functionality. Strategies to prevent or ameliorate the negative effects of PM2.5 exposure on BM-residing stem cells and to maintain the regenerative capacity of those cells must also be investigated. By focusing on the complex relationship between PM2.5 and BM-resident stem cells, this review highlights the importance of specific measures directed at safeguarding human health in the face of rising air pollution.

Exp Mol Med. 2024 Feb;56(1):118-128. doi: 10.1038/s12276-023-01149-z.
https://pubmed.ncbi.nlm.nih.gov/38200155/