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Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration.

  • 작성자

    Sekyu Choi
  • 작성일자

    2024-03-22
  • 조회수

    1146
Sekyu Choi( sekyuchoi@postech.ac.kr )
2021-PresentAssistant Professor, Department of Life Sciences, POSTECH 
2021Research Associate, Dept. of Stem Cell and Regenerative Biology/HSCI, Harvard University
2016-2021Postdoctoral fellow, Deptartment of Stem Cell and Regenerative Biology/HSCI, Harvard University
2014-2016Postdoctoral fellow, IMBG, Seoul National University
2007-2014PhD, Department of Biological Sciences, KAIST
2001-2007BS, Department of Life Sciences, Sogang University

Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration.

Hair follicles, which are connected to sebaceous glands in the skin, undergo cyclic periods of regeneration, degeneration, and rest throughout adult life in mammals. The crucial function of hair follicle stem cells is to maintain these hair growth cycles. Another vital aspect is the activity of melanocyte stem cells, which differentiate into melanin-producing melanocytes, contributing to skin and hair pigmentation. Sebaceous gland stem cells also have a pivotal role in maintaining the skin barrier by regenerating mature sebocytes. These stem cells are maintained in a specialized microenvironment or niche and are regulated by internal and external signals, determining their dynamic behaviors in homeostasis and hair follicle regeneration. The activity of these stem cells is tightly controlled by various factors secreted by the niche components around the hair follicles, as well as immune-mediated damage signals, aging, metabolic status, and stress. In this study, we review these diverse stem cell regulatory and related molecular mechanisms of hair regeneration and disease conditions. Molecular insights would provide new perspectives on the disease mechanisms as well as hair and skin disorder treatment.

Exp Mol Med. 2024 Feb;56(1):110-117. doi: 10.1038/s12276-023-01151-5.
https://pubmed.ncbi.nlm.nih.gov/38182654/