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BMB Reports

Contribution of the nervous system to cancer progression

  • 작성자

    Chan Hee Lee
  • 작성일자

    2024-03-22
  • 조회수

    1210
Name: Chan Hee Lee ( chl22@hallym.ac.kr )
2021-presentAssistance Professor, Department of Biomedical Science, Hallym University, South Korea
2020-2021Postdoctoral researcher, UT Southwestern Medical Center, Texas, USA
2019-2020Research Assistant Professor, Ulsan University, College of Medicine, South Korea
2016-2019Postdoctoral researcher, Asan Institute for Life Sciences, South Korea
2011-2016Ph.D., Biomedical Science and Engineering Interdisciplinary Program, KAIST, South Korea

Contribution of the nervous system to cancer progression

Cancer progression is driven by genetic mutations, environmental factors, and intricate interactions within the Tumor Microenvironment (TME), encompassing a complex network involving neurotrophic factors. The interplay between cancer cells and peripheral nerves, particularly the impact of neurotrophic factors such as NGF, BDNF, and GDNF, are associated with poor prognosis across various cancer types. Moreover, sympathetic and parasympathetic autonomic regulation plays a significant role in influencing tumor growth. Sympathetic signaling predominantly promotes tumor progression, whereas the role of parasympathetic signaling varies among different cancer types. These effects can occur by directly affecting tumor cells or regulating immune cell functions within the TME. In addition, the sensory nerves significantly promote cancer progression. We also describe the contribution of the CNS to Cancer-Associated Cachexia (CAC), characterized by tissue wasting and a reduced quality of life. This process involves pathways via GDF15-GFRAL signaling and hypothalamic POMC neurons. Our review underscores the multifaceted interactions between the nervous system and cancer progression and presents promising avenues for targeted therapeutic strategies.