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BMB Reports

Interplay between epigenome and 3D chromatin structure

  • 작성자

    Minhee Park
  • 작성일자

    2023-12-21
  • 조회수

    1540
Name: Minhee Park ( minheepark@kaist.ac.kr )
2021-presentAssistant Professor, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)
2020-2021Postdoctoral research fellow, Stanford University, USA
2012-2019Ph.D., Biomedical Engineering, Boston Univeristy, USA

Interplay between epigenome and 3D chromatin structure

Epigenetic mechanisms, primarily mediated through histone and DNA modifications, play a pivotal role in orchestrating a cell's functional identity and response to environmental cues. Similarly, the spatial arrangement of chromatin within the three-dimensional (3D) nucleus has gained recognition as a significant factor influencing genomic function. Investigating the relationship between epigenetic regulation and 3D chromatin structure has revealed correlation and causality between these processes, from the global alignment of average chromatin structure with epigenetic marks to the nuanced correlations at smaller length scales. This review aims to dissect the biological significance and the interplay between the epigenome and 3D chromatin structure, while also exploring the underlying molecular mechanisms. By synthesizing insights from both experimental and modeling perspectives, we seek to offer a comprehensive understanding of their collaborative influence on cellular functions.


BMB Rep. 2023 Dec 6:6088. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/38052424/