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After cell death: the molecular machinery of efferocytosis

  • 작성자

    Daeho Park
  • 작성일자

    2023-11-27
  • 조회수

    422
Name: Daeho Park (daehopark@gist.ac.kr)
2012-present Professor, School of Life Sciences, GIST, Republic of Korea
2008-2012 Research Associate, Department of immunology and infectious disease, School of Medicine, University of Virginia, USA
2004-2008 PhD, Department of Cell Biology, School of Medicine, University of Virginia, USA
2003-2004 Researcher, School of Life Sciences, GIST, Republic of Korea
2001-2003 MS, School of Life Sciences, GIST, Republic of Korea
1994-2001 BS, Food Science and Technology, Seoul National University, Republic of Korea

After cell death: the molecular machinery of efferocytosis

Cells constituting a multicellular organism die in a variety of ways throughout life, and most of them die via apoptosis under normal conditions. The occurrence of apoptosis is especially prevalent during development and in tissues with a high cellular turnover rate, such as the thymus and bone marrow. Interestingly, although the number of apoptotic cells produced daily is known to be innumerable in a healthy adult human body, apoptotic cells are rarely observed. This absence is due to the existence of a cellular process called efferocytosis that efficiently clears apoptotic cells. Studies over the past decades have focused on how phagocytes are able to remove apoptotic cells specifically, swiftly, and continuously, resulting in defined molecular and cellular events. In this review, we will discuss the current understanding of the clearance of apoptotic cells at the molecular level.


Exp Mol Med. 2023 Aug; 55(8): 1644–1651.
https://pubmed.ncbi.nlm.nih.gov/37612408/