생화학분자생물학회

	Jaewon Ko( jaewonko@dgist.ac.kr )
	2022-present	Director, Center for Synapse Diversity and Specificity, DGIST, South Korea
	2018-present	Professor, Department of Brain Sciences, DGIST, South Korea
	2017-2018	Associate Professor, Department of Brain Sciences, DGIST, South Korea
	2011-2017	Assistant & Associate Professor, Department of Biochemistry, Yonsei University, South Korea
	2008-2011	Postdoctoral Researcher, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, USA
	2007-2008	Research Fellow, Department of Neuroscience, University of Texas Southwestern Medical Center, USA
	2005-2007	Researcher, KAIST, South Korea

Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization

The WAVE regulatory complex (WRC), composed of five components-Cyfip1/Sra1, WAVE/Scar, Abi, Nap1/Nckap1, and Brk1/HSPC300-is essential for proper actin cytoskeletal dynamics and remodeling in eukaryotic cells, likely by matching various patterned signals to Arp2/3-mediated actin nucleation. Accumulating evidence from recent studies has revealed diverse functions of the WRC in neurons, demonstrating its crucial role in dictating the assembly of molecular complexes for the patterning of various trans-synaptic signals. In this review, we discuss recent exciting findings on the physiological role of the WRC in regulating synaptic properties and highlight the involvement of WRC dysfunction in various brain disorders.

Exp Mol Med. 2023 Jun;55(6):1065-1075 doi: 10.1038/s12276-023-01004-1
https://www.ncbi.nlm.nih.gov/pubmed/37258575/