생화학분자생물학회

	Name: Jung-Hyun Lee ( jhlee1@uos.ac.kr )
	2022-present	Assistant Professor , Department of Life Science, University of Seoul
	2021-2022	Project leader, Institute of Molecular Virology, Ulm University, Germany
	2020-2020	Research assistant Professor, Florida Research and Innovation, Cleveland Clinic, USA
	2018-2020	Postdoctoral scholar, Department of Microbiology, The University of Chicago, USA
	2016-2018	Junior group leader, Department of Dermatology, University Hospital of Erlangen, Germany
	2014-2018	Postdoctoral fellow, Department of Dermatology, University Hospital of Erlangen, Germany
	2014	Ph.D., Molecular virology and Cancer biology, Friedrich-Alexander-University Erlangen-Nürnberg, Germany

The Complex Role of Extracellular Vesicles in HIV infection

All cells release membrane vesicles called as extracellular vesicles (EVs) during normal physiological and abnormal pathophysiological conditions. Growing evidence has revealed the EVs as an important messenger in intercellular communication. EVs have emerging roles in cellular responses and modulation of immune responses during virus infection. EVs contribute to trigger antiviral responses to restrict virus infection and replication. On the other hand, the role of EVs in facilitation of virus spread and pathogenesis has been widely documented. Depending on the cell of origin, EVs carry effector functions from one cell to the other by horizontal transfer of their bioactive cargos, including DNA, RNA, proteins, lipids, and metabolites. The diverse constituents of EVs can reflect the altered states of cells or tissues during virus infection, thereby offering a diagnostic readout. The exchanges of cellular and/or viral components by EVs can inform their therapeutic potential of EVs for infectious diseases. This review provides recent advances of EVs to explore the complex roles of EVs during virus infection and the therapeutic potential, focusing on HIV-1.


BMB Rep. 2023 Jun;56(6):335-340. doi: 10.5483/BMBRep.2023-0073.
https://pubmed.ncbi.nlm.nih.gov/37291055/