생화학분자생물학회

	Name: Yun Ju Kim ( yunjukim@yonsei.ac.kr )
	2022-present	Associate professor, Department of Systems Biology, Yonsei University
	2014-2022	Research fellow, Center for Plant Aging Center, Institute for Basic Science
	2010-2013	Postdoctoral research fellow, University of California, Riverside, USA
	2005-2010	Ph.D., Department of Botany and Plant Science, University of California, Riverside, USA

Crosstalk between RNA silencing and RNA quality control in plants

RNAs are pivotal molecules acting as messengers of genetic information and regulatory molecules for cellular development and survival. From birth to death, RNAs face constant cellular decision for the precise control of cellular function and activity. Most eukaryotic cells employ conserved machineries for RNA decay including RNA silencing and RNA quality control (RQC). In plants, RQC monitors endogenous RNAs and degrades aberrant and dysfunctional species, whereas RNA silencing promotes RNA degradation to repress the expression of selected endogenous RNAs or exogenous RNA derived from transgenes and virus. Interestingly, emerging evidences have indicated that RQC and RNA silencing interact with each by sharing target RNAs and regulatory components. Such interaction should be tightly organized for proper cellular survival. However, it is still elusive that how each machinery specifically recognizes target RNAs. In this review, we summarize recent advances on RNA silencing and RQC pathway and discuss potential mechanisms underlying the interaction between the two machineries.


BMB Rep. 2023 Jun;56(6):321-325. doi: 10.5483/BMBRep.2023-0049.
https://pubmed.ncbi.nlm.nih.gov/37156633/