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Neurovascular coupling in bone regeneration

  • 작성자

    Seungyong Lee
  • 작성일자

    2022-12-22
  • 조회수

    348
Seungyong Lee( leesy@inu.ac.kr )
2022 – Present Assistant Professor, Department of Physical Education, Incheon National University, South Korea
2021 – 2022 Assistant Professor, Department of Physiology, Midwestern University - Glendale, USA
2020 – 2021 Dean’s Postdoc to Faculty Transition Fellow, Department of Physiology and Pharmacology, University of Toledo College of Medicine, USA
2018 – 2020 Postdoctoral Research Fellow, Department of Pathology, Johns Hopkins University School of Medicine, USA
2013 – 2018 Ph.D., College of Nursing and Health Innovation, Department of Kinesiology, The University of Texas at Arlington, USA
2010 – 2013 MS, College of Education, Department of Kinesiology and Health Promotion, University of Kentucky, USA

Neurovascular coupling in bone regeneration

The mammalian skeletal system is densely innervated by both neural and vascular networks. Peripheral nerves in the skeleton include sensory and sympathetic nerves. The crosstalk between skeletal and neural tissues is critical for skeletal development and regeneration. The cellular processes of osteogenesis and angiogenesis are coupled in both physiological and pathophysiological contexts. The cellular and molecular regulation of osteogenesis and angiogenesis have yet to be fully defined. This review will provide a detailed characterization of the regulatory role of nerves and blood vessels during bone regeneration. Furthermore, given the importance of the spatial relationship between nerves and blood vessels in bone, we discuss neurovascular coupling during physiological and pathological bone formation. A better understanding of the interactions between nerves and blood vessels will inform future novel therapeutic neural and vascular targeting for clinical bone repair and regeneration.

Exp Mol Med. 2022 Nov;54(11):1844-1849. doi: 10.1038/s12276-022-00899-6.
https://pubmed.ncbi.nlm.nih.gov/36446849/