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BMB Reports

Engineered human cardiac tissues for modeling heart diseases

  • 작성자

    Seung-Woo Cho
  • 작성일자

    2022-12-22
  • 조회수

    879
Name: Seung-Woo Cho ( seungwoocho@yonsei.ac.kr )
2020-present Underwood Distinguished Professor, Yonsei University
2017-present Associate faculty, Institute for Basic Science (IBS)
2010-present Professor, Department of Biotechnology, Yonsei University
2007-2010 Postdoctoral associate, Department of Chemical Engineering, Massachusetts Institute of Technology, USA
1995-2006 B.S., M.S., Ph.D., Chemical Engineering, Seoul National University

Engineered human cardiac tissues for modeling heart diseases

Heart disease is one of the major life-threatening diseases with high mortality and incidence worldwide. Several model systems, such as primary cells and animals, have been used to understand heart diseases and establish appropriate treatments. However, they have limitations in accuracy and reproducibility in recapitulating disease pathophysiology and evaluating drug responses. In recent years, three-dimensional (3D) cardiac tissue models produced with tissue engineering and human cells have outperformed conventional models. In particular, integration of cell reprogramming technique with bioengineering platforms (e.g., microfluidics, scaffolds, bioprinting, biophysical stimuli) has facilitated development of heart-on-a-chip, cardiac spheroid/organoid, and engineered heart tissue (EHT) to recapitulate structural and functional features of native human heart. These cardiac models have improved heart disease modeling and toxicological evaluation. In this review, we summarize the cell types for fabrication of cardiac tissue models, introduce diverse 3D human cardiac tissue models, and discuss the strategies to enhance their complexity and maturity. Finally, recent studies to model various heart diseases are reviewed.


BMB Rep. 2022 Nov 29;5794. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36443005/