생화학분자생물학회

	Ja-Hyoung Ryu (jhryu@unist.ac.kr)
	2021-present	Professor, Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), South Korea
	2016-2021	Associate Professor, Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), South Korea
	2012-2016	Assistant Professor, Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), South Korea
	2007-2011	Post Doctoral Researcher, Department of Chemistry, University of Massachusetts-Amherst USA
	2002-2006	PhD, Department of Chemistry, Yonsei University, South Korea
	2000-2002	MS, Department of Chemistry, Yonsei University, South Korea

Biomimetic peptide self-assembly: interfacing with biomacromolecules to regulate cellular signaling

Supramolecular self-assembly represents a spontaneous and reversible process that bridges discrete molecular building blocks with nanoscale architecture through non-covalent interactions. By rationally tuning these interactions, diverse nanostructures can be precisely constructed, each exhibiting distinct physicochemical and functional properties. The dynamic and multivalent nature of supramolecular assemblies endows them with structural adaptability and cooperative binding, enabling responsiveness to environmental cues and amplification of weak molecular interactions. Nature provides abundant paradigms for such self-organization, in which organized supramolecular interfaces mediate complex biological functions. Inspired by these natural principles, artificial self-assembly systems have been engineered to emulate the hierarchical organization and functional adaptability of living systems. In this Review, we summarize recent advances in nature-inspired supramolecular assemblies, focusing on peptide-based systems that exploit the chemical diversity of amino acids to modulate biomacromolecular interactions and cellular signaling. Understanding these biomimetic design principles offers a foundation for developing next-generation functional materials that bridge molecular precision with biological functionality.

Exp Mol Med. 2026, 58, 1038-1052. doi: 0.1038/s12276-026-01691-6
https://pubmed.ncbi.nlm.nih.gov/41981101/