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BMB Reports

3D epigenomics and 3D epigenopathies

  • 작성자

    Ji Hun Kim
  • 작성일자

    2024-07-22
  • 조회수

    1014
Name: Ji Hun Kim ( jihkim@kaist.ac.kr )
2022-presentAssistant Professor, GSMSE, KAIST, Korea
2020-2022Investigator, GlaxoSmithKline, PA, USA
2016-2019Postdoctoral Researcher, University of Pennsylvania, PA, USA
2014-2016Postdoctoral Associate, The Jackson Laboratory, CT, USA
2010Visiting Scientist, University of Edinburgh, UK
2009-2014Ph.D. University of Melbourne, VIC, Australia
2008Bachelor of Science with Honours, University of Melbourne, VIC, Australia
2005-2007Bachelor of Biomedical Science, University of Melbourne, VIC, Australia

3D epigenomics and 3D epigenopathies

Mammalian genomes are intricately compacted to form the sophisticated 3 dimensional structures within the tiny nucleus, so called 3D genome folding. Despite its shapes reminiscent of entangled yarn, the rapid development of molecular and next-generation sequencing technologies has revealed that they are highly organized in the hierarchical order that delicately affects transcription activities. An increasing number of evidence suggests that 3D genome folding is implicated in diseases, leaving us a clue on how to identify novel therapeutic approaches. In this review, we will study what 3D genome folding means in epigenetics, what types of 3D genome structures are there, how they are formed, and how the technologies have developed to explore them. We will also discuss the pathological implications of 3D genome folding. Finally, we will be discussing how to leverage the 3D genome folding and engineering for future studies.


BMB Rep. 2024 May;57(5):216-231. doi: 10.5483/BMBRep.2023-0249
https://pubmed.ncbi.nlm.nih.gov/38627948/