생화학분자생물학회입니다.
3D epigenomics and 3D epigenopathies
작성자
Ji Hun Kim작성일자
2024-07-22조회수
1014Name: Ji Hun Kim ( jihkim@kaist.ac.kr ) | ||
2022-present | Assistant Professor, GSMSE, KAIST, Korea | |
2020-2022 | Investigator, GlaxoSmithKline, PA, USA | |
2016-2019 | Postdoctoral Researcher, University of Pennsylvania, PA, USA | |
2014-2016 | Postdoctoral Associate, The Jackson Laboratory, CT, USA | |
2010 | Visiting Scientist, University of Edinburgh, UK | |
2009-2014 | Ph.D. University of Melbourne, VIC, Australia | |
2008 | Bachelor of Science with Honours, University of Melbourne, VIC, Australia | |
2005-2007 | Bachelor of Biomedical Science, University of Melbourne, VIC, Australia |
3D epigenomics and 3D epigenopathies
Mammalian genomes are intricately compacted to form the sophisticated 3 dimensional structures within the tiny nucleus, so called 3D genome folding. Despite its shapes reminiscent of entangled yarn, the rapid development of molecular and next-generation sequencing technologies has revealed that they are highly organized in the hierarchical order that delicately affects transcription activities. An increasing number of evidence suggests that 3D genome folding is implicated in diseases, leaving us a clue on how to identify novel therapeutic approaches. In this review, we will study what 3D genome folding means in epigenetics, what types of 3D genome structures are there, how they are formed, and how the technologies have developed to explore them. We will also discuss the pathological implications of 3D genome folding. Finally, we will be discussing how to leverage the 3D genome folding and engineering for future studies.
BMB Rep. 2024 May;57(5):216-231. doi: 10.5483/BMBRep.2023-0249
https://pubmed.ncbi.nlm.nih.gov/38627948/