생화학분자생물학회

	Name: CHANG H. KIM ( CHHKIM@UMICH.EDU )
	2017-present	Kenneth and Judy Betz Professor, Mary H. Weiser Food Allergy Center, University of Michigan
	2017-present	Professor, Department of Pathology, University of Michigan
	2010-2017	Professor, Department of Pathobiology (Biomedical Engineering, and Biology), Purdue University
	2006-2010	Associate Professor, Department of Pathobiology, Purdue University
	2002-2006	Fellow, Department of Pathology, Stanford University
	1999-2002	Ph.D. student, Department of Microbiology and Immunology, Indiana University School of Medicine
	1995-1998	Scientist, LG Chem LTD
	1990-1992	MS student, Biological Engineering, KAIST
	1986-1990	BS, Biological Science, KAIST

Regulation of Allergies Across the Body by Microbial Metabolites

Allergies are adverse immune responses to typically harmless substances, known as allergens. While allergies can involve diverse immune responses, type 2 immune responses that induce acute hypersensitivity mediated by mast cells, eosinophils, and basophils are the major mechanisms underlying allergic disorders. Allergic diseases include atopic dermatitis, allergic rhinitis, food allergies, and asthma. The onset and persistence of allergic disorders are influenced by genetic factors, pre-existing illnesses, age, environmental conditions, and other lifestyle factors. Particularly, diet and microbiomes significantly affect the incidence of various allergic diseases in the skin, lung, and intestine. Individuals prone to develop allergic diseases often have impaired and skewed microbial diversification over the first year of life, and this can lead to altered levels of microbial metabolites in the intestine and inflamed tissues. Microbial metabolites, such as short-chain fatty acids, indole metabolites, and bile acids, can exert specific regulatory effects on the various components of the immune system, such as barrier epithelial cells and immune cells, including dendritic cells, macrophages, T cells, B cells, innate lymphoid cells, and mast cells. Microbial metabolites can also promote immune tolerance to allergenic substances by strengthening regulatory T cells. Understanding the role of these metabolites can lead to better prevention and control of allergic diseases. This review will examine current research progress on the interactive relationship between microbial metabolites and allergic diseases and discuss relevant ways to improve allergic disorders.


Exp Mol Med. 2026 Feb 18. doi: 10.1038/s12276-026-01642-1.
https://pubmed.ncbi.nlm.nih.gov/41708997/