생화학분자생물학회

	Kyung Hwa Kim( kyungkim@dau.ac.kr )
	2019-present	Assistant Professor, Department of Health Care & Science, College of Health Sciences, Dong-A University, South Korea
	2017-2019	Research Professor, Department of Physiology, College of Korean Medicine, Kyung Hee University, South Korea
	2014-2017	Postdoctoral Fellow, Leonard Davis School of Gerontology, University of Southern California, USA
	2012-2014	Postdoctoral Fellow, Institute for Systems Biology, USA
	2007-2012	PhD, Department of Biochemistry and Molecular Biology, College of Medicine, Seoul National University, South Korea
	2004-2006	MS, Department of Physiology , College of Medicine, Yonsei University, South Korea
	2001-2002	Nurse, Intensive Care Unit, Korea University Anam Hospital, South Korea
	1997-2001	BS, Department of Physiology , College of Nursing, Korea University, South Korea

Socialized mitochondria: mitonuclear crosstalk in stress

Traditionally, mitochondria are considered sites of energy production. However, recent studies have suggested that mitochondria are signaling organelles that are involved in intracellular interactions with other organelles. Remarkably, stressed mitochondria appear to induce a beneficial response that restores mitochondrial function and cellular homeostasis. These mitochondrial stress-centered signaling pathways have been rapidly elucidated in multiple organisms. In this review, we examine current perspectives on how mitochondria communicate with the rest of the cell, highlighting mitochondria-to-nucleus (mitonuclear) communication under various stresses. Our understanding of mitochondria as signaling organelles may provide new insights into disease susceptibility and lifespan extension.

Exp Mol Med. 2024 May;56(5):1033-1042. doi: 10.1038/s12276-024-01211-4.
https://pubmed.ncbi.nlm.nih.gov/38689084/