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Entosis: the core mechanism and crosstalk with other cell death programs

  • 작성자

    Sung Eun Kim
  • 작성일자

    2024-07-22
  • 조회수

    871
Sung Eun Kim( sek19@korea.ac.kr )
2022-presentAssociate Professor, Department of Biosystems and Biomedical Sciences, Korea University, South Korea
2019-2022Assistant Professor, Department of Biosystems and Biomedical Sciences, Korea University, Seoul, South Korea
2016-2019Post-doctoral fellow, University of California, San Francisco, USA
2009-2016PhD, Cell and Development Biology (BCMB Allied Program), Weill Cornell Graduate School of Medical Sciences & Memorial Sloan Kettering Cancer, New York, USA
2008-2009Research technician, Korea University, South Korea
2006-2008MS, Animal Biotechnology and Genetic Engineering, Korea University, Seoul, South Korea
2002-2006BS, Biotechnology and Genetic Engineering, Korea University, Seoul, South Korea

Entosis: the core mechanism and crosstalk with other cell death programs

Cell death pathways play critical roles in organism development and homeostasis as well as in the pathogenesis of various diseases. While studies over the last decade have elucidated numerous different forms of cell death that can eliminate cells in various contexts, how certain mechanisms impact physiology is still not well understood. Moreover, recent studies have shown that multiple forms cell death can occur in a cell population, with different forms of death eliminating individual cells. Here, we aim to describe the known molecular mechanisms of entosis, a non-apoptotic cell engulfment process, and discuss signaling mechanisms that control its induction as well as its possible crosstalk with other cell death mechanisms.

Exp Mol Med. 2024 Apr;56(4):870-876. doi: 10.1038/s12276-024-01227-w.
https://pubmed.ncbi.nlm.nih.gov/38565900/