생화학분자생물학회

	Name: Maria Ciofani, PhD ( maria.ciofani@duke.edu )
	2021-present	Associate Professor of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA
	2020-present	Associate Professor of Integrative Immunobiology, Duke University School of Medicine, Durham, NC, USA
	2013-2020	Assistant Professor of Immunology, Duke University School of Medicine, Durham, NC, USA
	2007-2013	Postdoctoral Fellow, Dept of Pathology, New York University, NY, USA
	2000-2007	PhD, Dept of Immunology, University of Toronto, Canada

Th17 cell pathogenicity in autoimmune disease

T helper 17 (Th17) cells have been implicated in numerous inflammatory autoimmune diseases. Clinical benefits from targeting Th17 cell-related cytokines, such as IL-17 and IL-23, highlight how knowledge of Th17 cell development and effector function can be translated into treatments for inflammatory disease. Here we discuss the pathogenic roles of Th17 cells in autoimmune diseases such as multiple sclerosis, inflammatory bowel disease and psoriasis, with emphasis on the cytokines, transcriptional regulators and metabolites that influence Th17 cell differentiation and pathogenicity. Moreover, we address how intestinal environments and physiological responses affect Th17 cells in autoimmune diseases. We also examine current and emerging therapeutic strategies aimed at regulating Th17 cell-driven inflammation to mitigate autoimmune diseases.


Exp Mol Med. 2025 Sep;57(9):1913-1927. doi: 10.1038/s12276-025-01535-9.
https://pubmed.ncbi.nlm.nih.gov/40887501/