생화학분자생물학회입니다.
Gut microbiota-generated metabolites: missing puzzles to hosts’ health, diseases, and aging
작성자
Dongryeol Ryu작성일자
2024-07-22조회수
855Name: Dongryeol Ryu ( dryu@gist.ac.kr ) | ||
2023-present | Associate Professor, Department of Biomedical Science and Engineering, GIST, Korea | |
2019-2023 | Assistant Professor, SKKU School of Medicine, Korea | |
2017-2019 | Assistant Professor, Pusan National University, Korea | |
2016-2017 | Amazentis SA, EPLF Innovation Park, Switzerland | |
2010-2016 | Postdoctoral research fellow, EPFL, Switzerland | |
2006-2010 | Ph.D., Department of Mol Cell Bio, SKKU School of Medicine, Korea |
Gut microbiota-generated metabolites: missing puzzles to hosts’ health, diseases, and aging
Gut microbiota, an intricate community of bacteria residing in the gastrointestinal system, assumes a pivotal role in various physiological processes. Beyond its function in food breakdown and nutrient absorption, gut microbiota exerts a profound influence on immune and metabolic modulation by producing diverse gut microbiota-generated metabolites (GMGM). These small molecules hold potential to impact host health via multiple pathways, which exhibit remarkable diversity and have gained escalating attention in recent studies. Here, we elucidate the intricate implications and significant impacts of four specific metabolites, including Urolithin A (UA), equol, Trimethylamine N-oxide (TMAO), and imidazole propionate, in shaping human health. Meanwhile, we also look into the advanced research on GMGM, which demonstrate promising curative effects and hold great potential for further clinical therapies. Notably, the emergence of positive outcomes from clinical trials involving GMGM, typified by UA, emphasizes their promising prospects in the pursuit for improved health and longevity. Collectively, the multifaceted impacts of GMGM present intriguing avenues for future research and therapeutic interventions.
BMB Rep. 2024 May;57(5):207-215. doi: 10.5483/BMBRep.2024-0022
https://pubmed.ncbi.nlm.nih.gov/38627947/