생화학분자생물학회

	Name: Jae-Hyun Yang ( jaehyunyang@kaist.ac.kr )
	2024-present	Assistant professor, Department of Brain & Cognitive Sciences, KAIST, Korea
	2012-2024	Postdoctoral fellow/Research associate, Harvard Medical School, USA
	2011-2012	Postdoctoral fellow, Sungkyunkwan University, Korea
	2007-2011	Ph.D., School of Pharmacy, Sungkyunkwan University, Korea

Epigenetic Aging and Rejuvenation of the Brain: Drivers, Consequences, and Interventions

Evolution has tuned epigenetic resilience to preserve chromatin organization, transcriptional networks, and cellular identity under relentless stress. Over time, however, all eukaryotic life faces an inevitable rise in entropy that erodes the chromatin landscape at the genomic scale. This entropic decay of epigenetic information, epigenetic aging, is a driver of biological aging and systemic dysfunction. The brain is particularly vulnerable to epigenetic aging, with post-mitotic neurons accumulating lifelong chromatin erosion, and the glial epigenome drifting toward pro-inflammatory states. Defining the drivers and consequences of epigenetic aging in the brain forms the basis for restoring youthful chromatin landscapes, cellular identity, and cognitive capacity.