생화학분자생물학회

	Kyoung-Dong Kim( kdkim0122@cau.ac.kr )
	2023-present	Associate Professor, Department of Systems Biotechnology, Chung-Ang University, Korea
	2019-2023	Assistant Professor, Department of Systems Biotechnology, Chung-Ang University, Korea
	2016-2019	Associate Staff Scientist, The Wistar Institute, Philadelphia, USA
	2011-2016	Postdoctoral/ Research Fellow, The Wistar Institute, Philadelphia, USA
	2010-2011	Postdoctoral Fellow, Department of Biosciences, Seoul National University, South Korea
	2003-2010	PhD, Department of Biosciences, Seoul National University, South Korea

Viral Remodeling of the 4D Nucleome

The dynamic spatial organization of genomes across time, referred to as the four-dimensional nucleome (4DN), is a key component of gene regulation and biological fate. Viral infections can lead to a reconfiguration of viral and host genomes, impacting gene expression, replication, latency, and oncogenic transformation. This review provides a summary of recent research employing three-dimensional genomic methods such as Hi-C, 4C, ChIA-PET, and HiChIP in virology. We review how viruses induce changes in gene loop formation between regulatory elements, modify chromatin accessibility, and trigger shifts between A and B compartments in the host genome. We highlight the central role of cellular chromatin organizing factors, such as CTCF and cohesin, that reshape the 3D structure of both viral and cellular genomes. We consider how viral episomes, viral proteins, and viral integration sites can alter the host epigenome and how host cell type and conditions determine viral epigenomes. This review consolidates current knowledge of the diverse host-viral interactions that impact the 4DN.

Exp Mol Med. 2024 April 25; 56:799-808. doi: 10.1038/s12276-024-01207-0.
https://www.ncbi.nlm.nih.gov/pubmed/38658699