생화학분자생물학회

	Name: Ji Hun Kim ( jihkim@kaist.ac.kr )
	2022-present	Assistant Professor, GSMSE, KAIST, Korea
	2020-2022	Investigator, GlaxoSmithKline, PA, USA
	2016-2019	Postdoctoral Researcher, University of Pennsylvania, PA, USA
	2014-2016	Postdoctoral Associate, The Jackson Laboratory, CT, USA
	2010	Visiting Scientist, University of Edinburgh, UK
	2009-2014	Ph.D. University of Melbourne, VIC, Australia
	2008	Bachelor of Science with Honours, University of Melbourne, VIC, Australia
	2005-2007	Bachelor of Biomedical Science, University of Melbourne, VIC, Australia

3D epigenomics and 3D epigenopathies

Mammalian genomes are intricately compacted to form the sophisticated 3 dimensional structures within the tiny nucleus, so called 3D genome folding. Despite its shapes reminiscent of entangled yarn, the rapid development of molecular and next-generation sequencing technologies has revealed that they are highly organized in the hierarchical order that delicately affects transcription activities. An increasing number of evidence suggests that 3D genome folding is implicated in diseases, leaving us a clue on how to identify novel therapeutic approaches. In this review, we will study what 3D genome folding means in epigenetics, what types of 3D genome structures are there, how they are formed, and how the technologies have developed to explore them. We will also discuss the pathological implications of 3D genome folding. Finally, we will be discussing how to leverage the 3D genome folding and engineering for future studies.


BMB Rep. 2024 May;57(5):216-231. doi: 10.5483/BMBRep.2023-0249
https://pubmed.ncbi.nlm.nih.gov/38627948/