생화학분자생물학회

	Jin-Young Yang ( jyyang99@pusan.ac.kr )
	2024-present	Associate Professor, Department of Biology, Pusan National University, South Korea
	2020-2024	Assistant Professor, Department of Biology, Pusan National University, South Korea
	2015-2020	Post-doctoral fellow, Department of Immunology, MD Anderson Cancer Center, Houston, USA
	2011-2015	PhD, Department of Interdisciplinary Program in Agricultural Biotechnology, Seoul National University, South Korea
	2006-2008	MS, Department of Microbiology, Pusan National University, South Korea

Navigating mental health in space: gut-brain axis and microbiome dynamics

Long-term space travel presents significant mental health challenges, with documented psychological and neurological impacts observed during spaceflight and in simulated space environments. Terrestrial studies have highlighted the connection between the human gut microbiome and neuropsychological health, known as the gut-brain axis. Recent research has demonstrated alterations in astronauts' microbiomes during spaceflight. Here we explore interesting parallels between these microbiome changes in astronauts and those observed in terrestrial studies involving individuals experiencing psychological distress. Key areas of focus include how various space-related stressors impact the complex interplay between the gut microbiome, immune responses and mental health outcomes. This is illustrated by the effects of space radiation and circadian rhythm disruptions on the microbiome, as well as the roles of immune regulation and the integrity of gut and blood-brain barriers in shaping mental health outcomes through the gut-brain axis. Potential interventions and strategies for microbiome monitoring are suggested as critical to mitigating psychological risks during extended space missions. These findings underscore the need for further research to better understand how the microbiome responds to spaceflight environments and to develop targeted interventions that safeguard mental health during long-duration missions.

Exp Mol Med. (2025) 57:1152–1163. https://doi.org/10.1038/s12276-025-01488-z
https://pubmed.ncbi.nlm.nih.gov/40588528