생화학분자생물학회

	Je-Hyun Yoon ( jehyun-yoon@ouhsc.edu )
	2023-present	Associate Professor, Department of Oncology Science, University of Oklahoma, OK, USA
	2021-2023	Associate Professor, Department of Biochemistry and Molecular Biology, Medical University of South Carolina, SC, USA
	2015-2021	Assistant Professor, Department of Biochemistry and Molecular Biology, Medical University of South Carolina, SC, USA
	2011-2015	Visiting Fellow, National Institute on Aging, National Institutes of Health, USA
	2007-2011	PhD, Department of Molecular and Cellular Biology, University of Arizona, AZ, USA

Long noncoding RNAs regulating enzymatic reactions in cancer

Long noncoding RNAs (lncRNAs) have emerged as critical regulators of cancer development and progression by modulating enzymatic reactions involved in cellular metabolism and protein modifications. These noncoding transcripts exert their roles through molecular interactions with target proteins. Here we explore the diverse mechanisms through which lncRNAs optimize enzymatic reactions in metabolic processes and protein modifications, both of which are fundamental to the growth, adaptation, and survival of cancer cells. These processes, often dysregulated during cancer progression, are modulated by lncRNAs through direct interactions with specific proteins, underscoring their critical role in oncogenesis. Key research findings are summarized to provide a comprehensive understanding of the roles of lncRNAs in modulating these cellular processes. This Review offers an in-depth overview of the complex regulatory networks through which lncRNAs influence cancer pathogenesis and provides essential insights for the development of future therapeutic strategies.

Exp Mol Med. 2025 Aug;57(8):1641-1650. https://doi.org/10.1038/s12276-025-01464-7
https://pubmed.ncbi.nlm.nih.gov/40804479/