생화학분자생물학회

	Sujin Park ( sujin.park@ibs.re.kr )
	2022.09-	Senior researcher, Center for Genome Engineering, Institute for Basic Science (IBS)
	2022.01-2022.07	Research associate, Growth and Development Department; Laboratory of Prof. Michael N. Hall, Biozentrum, University of Basel
	2015-2021	Post-doctoral Fellow, Biochemistry Department; Laboratory of Prof. Michael N. Hall (Discoverer of TOR), Biozentrum, University of Basel
	2013-2015	Post-doctoral Fellow, Department of Biomedical Science; Laboratory of Prof. Jin Won Cho, Yonsei University
	2010-2013	Ph.D., Glycobiology/Cell Biology; Laboratory of Distinguishable Prof. Jürgen Roth (Co-inventor of immune-gold labeling for TEM), Yonsei University
	2009-2010	Staff scientist, Laboratory of Prof. Jin Won Cho, Yonsei University
	2007-2009	M.S., Glycobiology; Laboratory of Prof. Jin Won Cho, Yonsei University
	2003-2007	B.S., Biology, Yonsei University

Metabolic reprogramming in hepatocellular carcinoma: mechanisms and therapeutic implications

Hepatocellular carcinoma features extensive metabolic reprogramming. This includes alterations in major biochemical pathways such as glycolysis, the pentose phosphate pathway, amino acid metabolism and fatty acid metabolism. Moreover, there is a complex interplay among these altered pathways, particularly involving acetyl-CoA (coenzyme-A) metabolism and redox homeostasis, which in turn influences reprogramming of other metabolic pathways. Understanding these metabolic changes and their interactions with cellular signaling pathways offers potential strategies for the targeted treatment of hepatocellular carcinoma and improved patient outcomes. This review explores the specific metabolic alterations observed in hepatocellular carcinoma and highlights their roles in the progression of the disease.

Experimental & Molecular Medicine; https://doi.org/10.1038/s12276-025-01415-2
https://pubmed.ncbi.nlm.nih.gov/40025169/