생화학분자생물학회

	Name: Chang Hwa Jung ( chjung@kfri.re.kr )
	2011-present	Principal Researcher, Food Functionality Research Division, Korea Food Research Institute
	2007-2011	Postdoctoral, Dept. BMBB, University of Minnesota, Minneapolis
	2006-2007	Postdoctoral, Dept. of Genetic Engineering, Sungkyunkwan University
	2005-2006	Postdoctoral, College of Oriental Medicine, Kyung Hee University
	2001-2005	Ph.D., Department of Food Biotechnology, Korea University
	Name: Jiyun Ahn ( jyan@kfri.re.kr )
	2025-present	Head, Aging Research Group, Korea Food Research Institute
	2023-present	Chief Major Professor, Department of Food Biotechnology, UST
	2017-2022	Professor, Department of Food Biotechnology, UST
	2001-2024	Principal Researcher, Aging and Metabolism Research Group, Korea Food Research Institute
	2002-2006	Ph.D., Department of Veterinary Medicine, Konkuk University

Precision Genonutrition for Healthy Lifespan

Aging is a multifactorial and heterogeneous biological process, where chronological age alone does not accurately reflect an individual’s functional or physiological state. The emerging discipline of precision geronutrition integrates the principles of geroscience with precision nutrition, aiming to delay the onset of age-related functional decline by modulating fundamental molecular mechanisms, such as nutrient-sensing pathways (mTOR, AMPK, and sirtuins), inflammaging, and oxidative stress. A major barrier to progress has been the absence of validated biomarkers that can quantify biological aging and assess intervention efficacy. Recent advances in biological aging clocks, in particular DNA methylation–based epigenetic clocks, provide powerful tools to objectively measure biological age, and evaluate the impact of nutritional interventions. This review discusses how personalized dietary strategies, guided by multi-omics data (genomic, metabolomic, and microbiome profiles), can decelerate aging trajectories. We propose that individualized daily nutrition, aligned with an individual’s unique biological characteristics, represents a targeted and actionable approach to extend healthspan. The integration of dynamic aging clocks into nutritional intervention frameworks will be essential to transition from a disease-oriented model to a preventive, healthspan-centered paradigm. Future challenges include large-scale clinical validation, standardization of aging biomarkers, cost reduction, and translation into public health and clinical applications.


BMB Rep. 2025 Dec 18: 6693. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/41407319/