생화학분자생물학회

	Name: Dongryeol Ryu ( dryu@gist.ac.kr )
	2023-present	Associate Professor, Department of Biomedical Science and Engineering, GIST, Korea
	2019-2023	Assistant Professor, SKKU School of Medicine, Korea
	2017-2019	Assistant Professor, Pusan National University, Korea
	2016-2017	Amazentis SA, EPLF Innovation Park, Switzerland
	2010-2016	Postdoctoral research fellow, EPFL, Switzerland
	2006-2010	Ph.D., Department of Mol Cell Bio, SKKU School of Medicine, Korea

Gut microbiota-generated metabolites: missing puzzles to hosts’ health, diseases, and aging

Gut microbiota, an intricate community of bacteria residing in the gastrointestinal system, assumes a pivotal role in various physiological processes. Beyond its function in food breakdown and nutrient absorption, gut microbiota exerts a profound influence on immune and metabolic modulation by producing diverse gut microbiota-generated metabolites (GMGM). These small molecules hold potential to impact host health via multiple pathways, which exhibit remarkable diversity and have gained escalating attention in recent studies. Here, we elucidate the intricate implications and significant impacts of four specific metabolites, including Urolithin A (UA), equol, Trimethylamine N-oxide (TMAO), and imidazole propionate, in shaping human health. Meanwhile, we also look into the advanced research on GMGM, which demonstrate promising curative effects and hold great potential for further clinical therapies. Notably, the emergence of positive outcomes from clinical trials involving GMGM, typified by UA, emphasizes their promising prospects in the pursuit for improved health and longevity. Collectively, the multifaceted impacts of GMGM present intriguing avenues for future research and therapeutic interventions.


BMB Rep. 2024 May;57(5):207-215. doi: 10.5483/BMBRep.2024-0022
https://pubmed.ncbi.nlm.nih.gov/38627947/