생화학분자생물학회입니다.
Emerging insights into transcriptional condensates
작성자
Won-Ki Cho작성일자
2024-07-22조회수
879Won-Ki Cho( wonkicho@kaist.ac.kr ) | ||
2023-Present | Associate Professor, Department of Biological Sciences, KAIST | |
2019-2023 | Assistant Professor, Department of Biological Sciences, KAIST | |
2014-2019 | Postdoctoral Researcher, Department of Physics, MIT | |
2007-2013 | Ph.D. in Physics, POSTECH | |
2002-2007 | B.S. in Physics, POSTECH |
Emerging insights into transcriptional condensates
Eukaryotic transcription, a fundamental process that governs cell-specific gene expression, has long been the subject of extensive investigations in the fields of molecular biology, biochemistry, and structural biology. Recent advances in microscopy techniques have led to a fascinating concept known as “transcriptional condensates.” These dynamic assemblies are the result of a phenomenon called liquid‒liquid phase separation, which is driven by multivalent interactions between the constituent proteins in cells. The essential proteins associated with transcription are concentrated in transcriptional condensates. Recent studies have shed light on the temporal dynamics of transcriptional condensates and their potential role in enhancing the efficiency of transcription. In this article, we explore the properties of transcriptional condensates, investigate how they evolve over time, and evaluate the significant impact they have on the process of transcription. Furthermore, we highlight innovative techniques that allow us to manipulate these condensates, thus demonstrating their responsiveness to cellular signals and their connection to transcriptional bursting. As our understanding of transcriptional condensates continues to grow, they are poised to revolutionize our understanding of eukaryotic gene regulation.
Exp Mol Med. 2024 Apr;56(4):820-826. doi: 10.1038/s12276-024-01228-9
https://pubmed.ncbi.nlm.nih.gov/38658705/