간행물

생화학분자생물학회입니다.


EMM

Understanding the contextual functions of C1q and LAIR-1 and their applications

  • 작성자

    Myoungsun Son
  • 작성일자

    2022-07-19
  • 조회수

    83
Myoungsun Son( mson@northwell.edu )
2017-presentAssistant Professor, Department of Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell, New York, USA
2014-presentAssistant Professor, The Feinstein Institutes for Medical Research, New York, USA
2008-2014Post. Doc. The Feinstein Institutes for Medical Research, New York, USA
2007-2008Research Professor, Ewha Womans University, South Korea
2005-2007Post. Doc. Department of Molecular Life Science, Ewha Womans University, South Korea
2000-2005PhD, Department of Molecular Life Science, Ewha Womans University, South Korea
1995-1999BS, Department of Natural Science, Kyunghee University, South Korea

Understanding the contextual functions of C1q and LAIR-1 and their applications

The importance of the complement component C1q has been highlighted by its involvement in autoimmunity, infection, inflammatory diseases, and tumors. The unique tulip-like structure of C1q has both a collagen-like stalk (C1q tail) and heterotrimeric globular head (gC1q), each with different binding specificities, and the binding of these components to their respective receptors leads to functional complexities in the body and bridges innate and adaptive immunity. This review describes the fundamental roles of C1q in various microenvironments and focuses on the importance of the interactions of C1q and its receptors with the inhibitory receptor LAIR-1 in maintaining homeostasis. Current therapeutic opportunities modulating LAIR-1 are also discussed.

Exp Mol Med. 2022 May;54(5):567-572. doi: 10.1038/s12276-022-00774-4.
https://pubmed.ncbi.nlm.nih.gov/3556258