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BmB Reports

Roles of heterogenous hepatic macrophages in the progression of liver diseases

  • 작성자

    Yong-Hyun Han
  • 작성일자

    2022-07-19
  • 조회수

    81
Name: Yong-Hyun Han ( yhhan1015@kangwon.ac.kr )
2020-PresentAssistant Professor, College of Pharmacy, Kangwon National University, South Korea
2019-2020Postdoctoral Research Associate, Department of Pathology and Immunology, Washignton University in St. Louis, USA
2011-2018Ph.D., College of Pharmacy, Seoul National University, South Korea
2007-2011B.S., College of Pharmacy, Kangwon National University, South Korea

Roles of heterogenous hepatic macrophages in the progression of liver diseases

Hepatic macrophages are key immune cells associated with the broad ranges of liver diseases including steatosis, inflammation and fibrosis. Hepatic macrophages interact with other immune cells and orchestrate hepatic immune circumstances. Recently, the heterogenous populations of hepatic macrophages have been discovered termed residential Kupffer cells and monocyte-derived macrophages, and identified their distinct population dynamics during the progression of various liver diseases. Liver injury lead to Kupffer cells activation with induction of inflammatory cytokines and chemokines, which triggers recruitment of inflammatory monocyte-derived macrophages. To understand liver pathology, the functions of different subtypes of liver macrophages should be regarded with different perspectives. In this review, we summarize recent advances in the roles of hepatic macrophages under liver damages and suggest hepatic macrophages as promising therapeutic targets for treating liver diseases.


BMB Rep. 2022 Apr;55(4):166-174.
https://pubmed.ncbi.nlm.nih.gov/35321784/