생화학분자생물학회입니다.
Roles of heterogenous hepatic macrophages in the progression of liver diseases
작성자
Yong-Hyun Han작성일자
2022-07-19조회수
81Name: Yong-Hyun Han ( yhhan1015@kangwon.ac.kr ) | ||
2020-Present | Assistant Professor, College of Pharmacy, Kangwon National University, South Korea | |
2019-2020 | Postdoctoral Research Associate, Department of Pathology and Immunology, Washignton University in St. Louis, USA | |
2011-2018 | Ph.D., College of Pharmacy, Seoul National University, South Korea | |
2007-2011 | B.S., College of Pharmacy, Kangwon National University, South Korea |
Roles of heterogenous hepatic macrophages in the progression of liver diseases
Hepatic macrophages are key immune cells associated with the broad ranges of liver diseases including steatosis, inflammation and fibrosis. Hepatic macrophages interact with other immune cells and orchestrate hepatic immune circumstances. Recently, the heterogenous populations of hepatic macrophages have been discovered termed residential Kupffer cells and monocyte-derived macrophages, and identified their distinct population dynamics during the progression of various liver diseases. Liver injury lead to Kupffer cells activation with induction of inflammatory cytokines and chemokines, which triggers recruitment of inflammatory monocyte-derived macrophages. To understand liver pathology, the functions of different subtypes of liver macrophages should be regarded with different perspectives. In this review, we summarize recent advances in the roles of hepatic macrophages under liver damages and suggest hepatic macrophages as promising therapeutic targets for treating liver diseases.
BMB Rep. 2022 Apr;55(4):166-174.
https://pubmed.ncbi.nlm.nih.gov/35321784/