생화학분자생물학회

	Jekyung Ryu( prof.love@snu.ac.kr )
	2022-present	Associate Professor, Department of Physics and Astronomy, Seoul National University, South Korea
	2016-2021	Postdoctoral Research Fellow, Cees Dekker Lab, Applied Science, TU Delft, The Netherlands
	2014-2015	Postdoctoral Research Fellow, National Creative Research Initiative Center for Single-Molecule Systems Biology, KAIST, South Korea
	2006-2014	PhD in Physics, KAIST, South Korea
	2002-2006	BS in Mathematics (Double major: Physics), KAIST, South Korea

Mechanism of phase condensation for chromosome architecture and function

Chromosomal phase separation is involved in a broad spectrum of chromosome organization and functional processes. Nonetheless, the intricacy of this process has left its molecular mechanism unclear. Here, we introduce the principles governing phase separation and its connections to physiological roles in this context. Our primary focus is contrasting two phase separation mechanisms: self-association-induced phase separation (SIPS) and bridging-induced phase separation (BIPS). We provide a comprehensive discussion of the distinct features characterizing these mechanisms and offer illustrative examples that suggest their broad applicability. With a detailed understanding of these mechanisms, we explore their associations with nucleosomes and chromosomal biological functions. This comprehensive review contributes to the exploration of uncharted territory in the intricate interplay between chromosome architecture and function.

Exp Mol Med. 2024 Apr;56(4):809-819. doi: 10.1038/s12276-024-01226-x.
https://pubmed.ncbi.nlm.nih.gov/38658703/