생화학분자생물학회

	Name: Lark Kyun Kim ( LKKIM@yuhs.ac )
	2016-present	Assistant / Associate Professor, Department of Biomedical Sciences, Yonsei University College of Medicine
	2014-2016	Associate Research Scientist, Department of Immunobiology, Yale School of Medicine, USA
	2009-2014	Postdoctoral Associate, Department of Immunobiology, Yale School of Medicine, USA
	2005-2008	Ph.D., Department of Biochemistry, Yonsei University
	Name: Un Yung Choi ( uychoi@kku.ac.kr )
	2023-present	Assistant Professor, Department of Microbiology, College of Medicine, Konkuk University
	2020-2023	Research Associate, Cleveland Clinic, USA
	2015-2020	Postdoctoral Fellow, University of Southern California, Keck School of Medicine, USA
	2006-2014	Ph.D., Department of Biochemistry, Yonsei University

Multifaceted roles of trained immunity in diverse pathological contexts

Trained immunity, an innate immune response characterized by enhanced cellular responsiveness, exhibits a profound memory akin to adaptive immunity. This phenomenon involves intricate metabolic and epigenetic reprogramming triggered by stimuli such as β-glucan and BCG, shaping innate immune memory. Following elucidation of the background on trained immunity, it is important to explore its multifaceted roles in various pathological contexts. In this review, we delve into the specific contributions of trained immunity in the intricate landscape of viral infections, tumorigenesis, and diverse inflammatory diseases, shedding light on its potential as a therapeutic target, and offering comprehensive understanding of its broader immunological implications.


BMB Rep. 2024 Oct;57(10):431-440
https://pubmed.ncbi.nlm.nih.gov/38835118/